Lesson Plan: B1.5.07


LESSON PLAN
Teacher Subject Period Date Year Ability LSA/Other Support
Science

Context and
Landmark
Assessment		 B1.5.07
Landmark Assessment: Progress Observation Opportunity
Remember to have high expectations
Lesson Title: Today we are learning about
How are new drugs developed?
Remember to check for PROGRESS
Focus on Knowledge, Skills and Understanding
Success Criteria: You will show your learning by...
  1. Traditionally drugs were extracted from plants and microorganisms.
  2. The heart drug digitalis originates from foxgloves.
  3. The painkiller aspirin originates from willow.
  4. Penicillin was discovered by Alexander Fleming from the Penicillium mould.
  5. Most new drugs are synthesised by chemists in the pharmaceutical industry. However, the starting point may still be a chemical extracted from a plant.
  6. New medical drugs have to be tested and trialled before being used to check that they are safe and effective.
  7. Preclinical testing is done in a laboratory using cells, tissues and live animals.
  8. Clinical trials use healthy volunteers and patients.
  9. Very low doses of the drug are given at the start of the clinical trial.
  10. If the drug is found to be safe, further clinical trials are carried out to find the optimum dose for the drug.
  11. In double blind trials, some patients are given a placebo.
  12. Students understand that the results of testing and trials are published only after scrutiny by peer review. (WS)
  13. Students should be able to describe the process of discovery and development of potential new medicines, including preclinical and clinical testing.
Think about how you can match the needs of ALL students
Keywords:
  • Optimum dose: The best amount of drug to treat a disease effectively (1)
  • Dose: The amount of drug given to a patient/volunteer (1)
  • Volunteers: People who offer to test out new drugs to see their side affects (1)
  • Preclinical testing: testing done in a laboratory using cells, tissues and live animals. (1)
Links: Literacy, Numeracy, SMSC, British values
Memory Anchor:

AFL/Key Questions:
  1. Where are drugs traditionally extracted from?
    Traditionally drugs were extracted from plants and microorganisms.
  2. Which plant does the heart drug digitalis orginate from?
    The heart drug digitalis originates from foxgloves.
  3. Which plant does the painkiller aspirin orginate from?
    The painkiller aspirin originates from willow.
  4. Who discovered pneicillin and from what?
    Penicillin was discovered by Alexander Fleming from the Penicillium mould.
  5. How are most new drugs synthesised by chemists?
    Most new drugs are synthesised by chemists in the pharmaceutical industry. However, the starting point may still be a chemical extracted from a plant.
  6. Why are new drugs tested and trialled before being used?
    New medical drugs have to be tested and trialled before being used to check that they are safe and effective.
  7. What happens during preclinical testing?
    Preclinical testing is done in a laboratory using cells, tissues and live animals.
  8. What happens during clinical trials?
    Clinical trials give the new drug to healthy volunteers and patients and observe the effects
  9. What level of dose is used at the start of the clinical trial?
    During the clinical trial very low doses of the drug are given at the start of the clinical trial.
  10. If the new drug is found to be safe during the initial clinical trial what do scientists do to the dosage?
    If the drug is found to be safe, further clinical trials are carried out to find the optimum dose for the drug.
  11. What does a double blind trial mean?
    In double blind trials, some patients are given a placebo but neither the scientist or the patients know who has the drug and who has the placebo
  12. What is the final stage of the drug trial?
    The final stage of a drug trial is for the drug to scruntised by peer review.
  13. What are the stages involved in developing a new drug?
    The stages involved in developing a drug include preclinical, clinical trials with healthy volunteers and patients, then further trails to establish dosage, final stage is for the findings to be peer reviewed.
Identify questions for high, middle, low and identify questioning techniques- Challenge questions

Learning Phases/Episodes
Think about how you can match the needs of ALL students
Differentiation: AGT, SEND, LLL, Disadvantaged
Remember to check for PROGRESS
Starter Activity Differentiation and Challenge question/task
  • Students to copy and complete the keywords.
  • Teacher reveals missing letters; Students correct mistakes;
  • Discuss the scientific meanings of the words.
  • Students to write down the definitions of the most important / new keywords.
  • Discuss the 'Memory Anchor'.
    • What does it show?
    • How does it relate to the what we are learning about today (title)?
Think about PACE – Develop, consolidate and deepen knowledge, skills and understanding
Teacher or Student lead? Differentiation and Challenge question/task
Progress Check Extension
Remember to give time to apply knowledge, skills and understanding
Teacher or Student lead? Differentiation and Challenge question/task
Progress Check Extension

Teacher or Student lead? Differentiation and Challenge question/task
Progress Check Extension

Teacher or Student lead? Differentiation and Challenge question/task
Progress Check Extension


Plenary Differentiation and Challenge question/task
  • Students to answer the 'Key Questions' with learning partners.
Progress Check
  • Teacher to reveal and discuss the answers to the questions.
 Extension
  • What have learnt about the 'Big Ideas' today?

Homework Differentiation and Challenge question/task