Lesson Plan: B1.5.08

LESSON PLAN

Teacher	Subject	Period	Date	Year	Ability	LSA/Other Support
	Science

Context and Landmark Assessment	B1.5.08 Landmark Assessment: Progress Observation Opportunity

Remember to have high expectations

Lesson Title: Today we are learning about
What are monoclonal antibodies?

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Focus on Knowledge, Skills and Understanding

Success Criteria:	You will show your learning by...
Students should be able to describe how monoclonal antibodies are produced. Monoclonal antibodies are produced from a single clone of cells. The antibodies are specific to one binding site on one protein antigen and so are able to target a specific chemical or specific cells in the body. Antibodies are produced by stimulating mouse lymphocytes to make a particular antibody. The lymphocytes are combined with a particular kind of tumour cell to make a cell called a hybridoma cell. The hybridoma cell can both divide and make the antibody. Single hybridoma cells are cloned to produce many identical cells that all produce the same antibody. A large amount of the antibody can be collected and purified. Students should be able to describe some of the ways in which monoclonal antibodies can be used. * Appreciate the power of monoclonal antibodies and consider any ethical issues (WS). Some examples [of monoclonal antibodies] include: ? for diagnosis such as in pregnancy tests ? in laboratories to measure the levels of hormones and other chemicals in blood, or to detect pathogens ? in research to locate or identify specific molecules in a cell or tissue by binding to them with a fluorescent ?dye to treat some diseases (e.g. cancer) Monochlonal antibodies are used to treat cancer. The antibody can be bound to a radioactive substance, a toxic drug or a chemical which stops cells growing and dividing. Monochlonal antibodies deliver the substance to the cancer cells without harming other cells in the body. Students are not expected to recall any specific tests or treatments but given appropriate information they should be able to explain how they work. Monoclonal antibodies create more side effects than expected. They are not yet as widely used as everyone hoped when they were first developed. * Evaluate the advantages and disadvantages of monoclonal antibodies.

Success Criteria:

You will show your learning by...

Students should be able to describe how monoclonal antibodies are produced.
Monoclonal antibodies are produced from a single clone of cells.
The antibodies are specific to one binding site on one protein antigen and so are able to target a specific chemical or specific cells in the body.
Antibodies are produced by stimulating mouse lymphocytes to make a particular antibody.
The lymphocytes are combined with a particular kind of tumour cell to make a cell called a hybridoma cell. The hybridoma cell can both divide and make the antibody.
Single hybridoma cells are cloned to produce many identical cells that all produce the same antibody.
A large amount of the antibody can be collected and purified.
Students should be able to describe some of the ways in which monoclonal antibodies can be used. * Appreciate the power of monoclonal antibodies and consider any ethical issues (WS).
Some examples [of monoclonal antibodies] include: ? for diagnosis such as in pregnancy tests ? in laboratories to measure the levels of hormones and other chemicals in blood, or to detect pathogens ? in research to locate or identify specific molecules in a cell or tissue by binding to them with a fluorescent ?dye to treat some diseases (e.g. cancer)
Monochlonal antibodies are used to treat cancer. The antibody can be bound to a radioactive substance, a toxic drug or a chemical which stops cells growing and dividing.
Monochlonal antibodies deliver the substance to the cancer cells without harming other cells in the body.
Students are not expected to recall any specific tests or treatments but given appropriate information they should be able to explain how they work.
Monoclonal antibodies create more side effects than expected. They are not yet as widely used as everyone hoped when they were first developed.
* Evaluate the advantages and disadvantages of monoclonal antibodies.

Think about how you can match the needs of ALL students

Keywords:

Links: Literacy, Numeracy, SMSC, British values

Memory Anchor:

AFL/Key Questions:

(Bio only) How are monoclonal antibodies produced?
Monoclonal antibodies are produced from a single clone of cells.
(Bio only) How many clone of cells produce monoclonal antibodies
Monoclonal antibodies are produced from a single clone of cells.
(Bio only) Why are monoclonal antibodies important?
Monoclonal antibodies are specific to one binding site on one protein antigen and so are able to target a specific chemical or specific cells in the body.
(Bio only) How can monoclonal antibodies produced?
Monoclonal antibodies are produced by stimulating mouse lymphocytes to make a particular antibody.
(Bio only) How are hybridoma cells made and why are they useful?
Lymphocytes from mice are combined with a particular kind of tumour cell to make a cell called a hybridoma cell. The hybridoma cell can both divide and make the antibody.
(Bio only) Why are single hybridoma cells cloned?
Single hybridoma cells are cloned to produce many identical cells that all produce the same antibody.
(Bio only) Why is the use of hybridoma cells important?
The use of hybridoma cells are important because a large amount of the antibodiy can be collected and purified
(Bio only) What ethical issues are there in the use of monochlonal antibodies?
The ethical issues surrounding monochlonal antibodies surround the extraction of lympocytes from white blood cells
(Bio only) List 6 ways that monoclonal antibodies can be used
Diagnosis in pregnancy tests to measure hormones and other chemicals in blood detect pathogens in the blood to locate or identify specific moleucles in cells or tissues by binding with fluorescent dye to treat diseases
(Bio only) How can monochlonal diseases be used to treat cancer?
The antibody can be bound to a radioactive substance, a toxic drug or a chemical which stops cells growing and dividing.
(Bio only) Does the use of monochlonal antibodies harm other cells in the body?
No, other cells are not harmed as they are specific for antigens
(Bio only) List examples of how monoclonal antibodies are useful as treatments or tests.
Monoclonal antibodies can be used in pregnacy tests. Glucose tests for diabetics. Testing for specific cancers.
(Bio only) What are the disadvantages of using monoclonal antibodies?
Monoclonal antibodies create more side effects than expected. They are not yet as widely used as everyone hoped when they were first developed.
(Bio only) What are the advantages of monoclonal antibodies?
Monoclonal antibodies enable fast treatment of diseases and may eradicate the need for human donars

Identify questions for high, middle, low and identify questioning techniques- Challenge questions

Learning Phases/Episodes

Think about how you can match the needs of ALL students
Differentiation: AGT, SEND, LLL, Disadvantaged
Remember to check for PROGRESS

Starter Activity	Differentiation and Challenge question/task
Students to copy and complete the keywords. Teacher reveals missing letters; Students correct mistakes; Discuss the scientific meanings of the words. Students to write down the definitions of the most important / new keywords. Discuss the 'Memory Anchor'. What does it show? How does it relate to the what we are learning about today (title)?

Think about PACE – Develop, consolidate and deepen knowledge, skills and understanding

Teacher or Student lead?	Differentiation and Challenge question/task

Progress Check	Extension

Remember to give time to apply knowledge, skills and understanding

Teacher or Student lead?	Differentiation and Challenge question/task

Progress Check	Extension

Teacher or Student lead?	Differentiation and Challenge question/task

Progress Check	Extension

Teacher or Student lead?	Differentiation and Challenge question/task

Progress Check	Extension

Plenary	Differentiation and Challenge question/task
Students to answer the 'Key Questions' with learning partners.
Progress Check Teacher to reveal and discuss the answers to the questions.	Extension What have learnt about the 'Big Ideas' today?

Homework	Differentiation and Challenge question/task